CO2 is a metal active gas. It is not inert. It causes more spatter by its nature, and it is like going backwards in the smoothness of the arc, although inductance can tame it somewhat. More smoke, and usually a dark, dull weld appearance from the oxidation that takes place. I've used, it and won't use it unless 100% necessary. It does penetrate but the spatter alone increases clean up time and makes spatter removal much more difficult as the BB's seem to freeze much more solidly to the metal. I figured the difference in clean up time, and given the way that I charge my customers (not to mention the hassle) it pays to run a mix.